Juventus, who have won only one of their last five games and have dropped 18 points from winning positions this season, stay on 80 points followed by Atalanta with 74 and Inter Milan on 73 with three games each to play.
Defending champions Bayern Munich must face Diego Simeone's Atletico Madrid after they were drawn together in Champions League Group A alongside Salzburg and Lokomotiv Moscow.
In a big blow to Real Madrid's title hopes, Real Betis held them to a goalless draw in their La Liga encounter on Sunday.
IMAGES from the football matches played across Europe on Sunday.
Milan replaced Gennaro Gattuso with former Sampdoria coach Giampaolo during the close season in a bid to improve on last season's fifth place and to take them back to the Champions League.
Bayern Munich edged past Werder Bremen 2-1 on Saturday for a Bundesliga record 13th consecutive win over them to stay three points clear at the top of the table.
Images from Sunday's action in La Liga, Serie A and Ligue 1.
Inter will be his sixth club in a career which began when he made his debut for Anderlecht as a 16-year-old and has taken him to Chelsea, West Bromwich Albion and Everton.
LaLiga leaders Barcelona's pursuit of a 27th Spanish title gained momentum after a 2-1 comeback win over Real Madrid.
Serie A leaders Juventus have been fined 30,000 euros and warned about the future conduct of their fans after they made racist chants during Wednesday's 2-1 win at home to Lazio.
Messi doesn't need to win a World Cup to prove his greatness, feels iconic former Argentine striker Hernan Crespo.
Alessandro Del Piero, almost certainly playing his last home game for Juventus at the age of 37, celebrated with a goal as the Serie A champions beat Atalanta 3-1 on Sunday to finish their campaign unbeaten.
Mourinho's side failed to turn their domination into more goals and things got edgy late on when Saville's shot evaded Gazzaniga who seemed slow to get down.
Serie A soccer matches in the northern Italian regions of Lombardy and Veneto will not be played on Sunday because of an outbreak of the coronavirus, the government said in a statement. The three impacted fixtures are clashes between Inter Milan and Sampdoria, Atalanta against Sassuolo and Hellas Verona against Cagliari. Italy is tackling the worst outbreak of coronavirus yet recorded in Europe, with two people dying in the north since Friday and nearly 60 infected.
Ronaldo's replacement Dybala scored in the 77th minute with a goal the Portuguese would have been proud of. After a quick exchange of passes, the Argentine twisted past Alessio Romagnoli and beat Gianluigi Donnarumma with a right foot shot.
News of all that's transpired on and off the football field.
Images from the Champions League Round of 16 matches.
AS Roma and Juventus lost on their domestic returns from midweek UEFA Champions League action as their miserable starts to the season continued. In England, frontrunners Liverpool and Chelsea fared better with wins while Valencia top the table on goal difference in Spain and Lazio, Udinese and champions Inter Milan share the lead in Italy.
Champions Juventus continued their resurgence by beating Hellas Verona 3-0 at home for an eighth successive Serie A victory as Inter Milan remained top after winning 1-0 at Empoli.
Inter Milan boss Jose Mourinho believes his former club Chelsea are making it difficult for him to sign Deco and Ricardo Carvalho.
Table-toppers Napoli, barely affected by injuries, have won five league matches in a row to extend their unbeaten run since the start of the season in both Serie A and the Champions League.
AS Roma clambered back to the top of Serie A, at least for a day, after Francesco Totti added to his collection of classic goals with a marvellous lob in Saturday's 2-1 win at Parma.
The Italian Super Cup between Inter Milan and Lazio is set to attract a full house of 80,000 to the Bird's Nest stadium in Beijing next month after a flurry of early ticket sales.
Serie A witnessed some breath-taking football action, especially when AC Milan could not convert the umpteen chances they had against Sassuolo while Inter went to top. In Ligue 1 action, all the star players found the net for PSG. Here are images from the soccer matches played across Europe on Sunday.
Juventus suffered their first defeat of the season at Lazio but the champions put pressure back on Antonio Conte's side by moving one point clear at the top
Giacomo Bonaventura's free kick earned Milan a 1-0 win over Pescara to move them into the top three of Serie A on Sunday.
Inter Milan's Serie A title hopes suffered a setback as they conceded a stoppage-time equaliser and were held 1-1 at home by relegation-threatened Carpi and leaders Napoli swept to a 4-2 win at Sampdoria.
Real Madrid's teenage Brazilian duo Vinicius Junior and Rodrygo Goes sent them top of La Liga as both scored in a 2-0 win over Osasuna on Wednesday.
Croatian forward Ante Budimir scored twice to help Osasuna earn a shock 4-2 home win over leaders Barcelona.
News of all that's transpired on and off the football field
Juventus, with 80 points, are eight clear of Inter Milan with four games each to play followed by Atalanta on 71 and Lazio fourth on 69.
Argentina's injured captain Lionel Messi has been named in a squad missing the suspended Javier Mascherano and Gonzalo Higuain for next month's World Cup qualifier against South America's bottom side Paraguay.
A round-up of Wednesday's action in the UEFA Champions League
Images from the football matches played across Europe on Sunday.
A summary of the opening day's action in the UEFA Champions league on Tuesday.
Images from the soccer matches played across Europe on Saturday.
News of all that's transpired on and off the football field
IMAGES from the soccer matches played across European leagues over the weekend.
Midfielder Riccardo Montolivo missed out on his second straight major tournament due to injury on Tuesday while Daniele De Rossi was included in Italy's 23-man squad for next month's European Championship in France.